A Context-Responsive LSTM based IoT Enabled E- Healthcare Monitoring System for Arrhythmia Detection

Detecting Arrhythmia, a life-threatening cardiac condition, in real-time is crucial for timely intervention and improved healthcare outcomes. Traditional manual methods for Arrhythmia detection using Electrocardiogram (ECG) signals are error-prone and resource-intensive. To address these limitations, this paper presents an automated system based on the Context Responsive Long Short-Term Memory (CR-LSTM) model for real-time Arrhythmia classification. The system leverages IoT technology to continuously monitor vital signs and effectively combines contextual information with temporal sensor data to accurately discern different types of Arrhythmias. The CR-LSTM model achieves an impressive accuracy of 99.72% in multiclass classification of Arrhythmias, making it a promising solution for dynamic healthcare settings and proactive personalized care

The performance of the jet trigger for the ATLAS detector during 2011 data taking

The performance of the jet trigger for the ATLAS detector at the LHC during the 2011 data taking period is described. During 2011 the LHC provided proton–proton collisions with a centre-of-mass energy of 7 TeV and heavy ion collisions with a 2.76 TeV per nucleon–nucleon collision energy. The ATLAS trigger is a three level system designed to reduce the rate of events from the 40 MHz nominal maximum bunch crossing rate to the approximate 400 Hz which can be written to offline storage. The ATLAS jet trigger is the primary means for the online selection of events containing jets. Events are accepted by the trigger if they contain one or more jets above some transverse energy threshold. During 2011 data taking the jet trigger was fully efficient for jets with transverse energy above 25 GeV for triggers seeded randomly at Level 1. For triggers which require a jet to be identified at each of the three trigger levels, full efficiency is reached for offline jets with transverse energy above 60 GeV. Jets reconstructed in the final trigger level and corresponding to offline jets with transverse energy greater than 60 GeV, are reconstructed with a resolution in transverse energy with respect to offline jets, of better than 4 % in the central region and better than 2.5 % in the forward direction

Whole-genome sequencing reveals host factors underlying critical COVID-19

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease

Management of Dentigerous Cyst Occurring in an Uncommon Maxillary Anterior Region – A Report of 2 Cases

Dentigerous cysts are rare in the maxillary anterior area with less than 10 cases reported. Trauma to the deciduous teeth can result in the formation of dentigerous cyst around the permanent successor. Here we are reporting two cases of dentigerous cyst around permanent incisors with overlying non vital deciduous teeth. Enucleation of the cyst was done in both the cases

Constitutive modeling of cellular-structured metals produced by additive manufacturing

© 2022Computational modeling is essential in the development and application of metal additive manufacturing (MAM). Most materials processed by laser or electron beam MAM exhibit a characteristic cellular structure, where the cell walls contain a higher dislocation density than the cell interior. This kind of structure is believed to be responsible for the enhanced properties of structural members produced by MAM. In this study, a constitutive description of MAM materials was developed to accurately simulate their mechanical response to loading. The modeling frame was given by the dislocation density evolution, with two distinctly different dislocation densities being considered: those in cell walls and cell interiors considered as two separate ‘phases’ of the material. By employing the constitutive model developed, numerical analyses were conducted for a broad range of MAM materials - from pure metals to alloys. A comparison of the numerical simulations with experimental data for Cu and Cu-Sn from literature demonstrated that the model provides an adequate description of its uniaxial tensile properties and the dislocation density variation. In particular, the influence of the dimensions of the cellular structure and the applied strain rate is accounted for faithfully. It is suggested that the model is applicable to a broader range of MAM-processed materials as well.11Nsciescopu

Unusual strain-induced martensite and absence of conventional grain refinement in twinning induced plasticity high-entropy alloy processed by high-pressure torsion

A Fe40Mn40Co10Cr10 twinning induced plasticity high-entropy alloy was processed by high-pressure torsion, and its microstructure and mechanical properties were studied. The results indicate the absence of typical grain refinement, but rather the original grain size was retained with the formation of strain-induced HCP martensitic phase.11Nsciescopu

Role of cellular structure on deformation twinning and hetero-deformation induced strengthening of laser powder-bed fusion processed CuSn alloy

© 2022 Elsevier B.V.The sub-grain cellular dislocation structure has been reported to be the primary reason for the enhanced mechanical properties in laser powder-bed fusion (LPBF) parts. In the current work, the contribution of the cellular dislocation structure to the yield strength of LPBF processed CuSn alloy is estimated to be ~45%. In addition, this work shows that the cellular dislocation structure significantly controls the deformation behavior of LPBF processed CuSn alloy by suppressing the formation of deformation twinning. Post-LPBF heat treatment with fully recrystallized microstructures devoid of cellular dislocation structure showed pronounced twinning activity. The reduced homogeneous slip length due to the fine dislocation cell structure ~600 nm and increased stacking fault energy due to the cellular Sn segregation significantly increased the activation energy for the nucleation and propagation of the partial dislocations and suppressed the deformation twinning in the as-built samples. Furthermore, the present work shows that cellular dislocation structure contributes significantly to the hetero-deformation induced strengthening, much higher than the heterogeneous grain structure in the LPBF samples.11Nsciescopu

Cryogenic tensile behavior of laser additive manufactured CoCrFeMnNi high entropy alloys

In the present work the microstructural evolution, tensile properties, and deformation behavior of additively manufactured equiatomic CoCrFeMnNi high entropy alloy (HEA) were investigated at a cryogenic temperature (77 K). Metal additive manufacturing components are known to have exceptional yield strength, without compromising ductility. Here, laser powder bed fusion (LPBF) and direct energy deposition (DED) additive manufacturing processes were chosen as the fabrication techniques and wrought CoCrFeMnNi HEA was also fabricated for comparison. The tensile behaviors at different temperatures (298 K and 77 K) indicated temperature-dependent strength and ductility in all the samples. In particular, the HEA processed by DED exhibited excellent strength and ductility, with exceptional strain hardening, compared to the LPBF and wrought samples at 77 K. Post-tensile microstructures revealed the formation of deformation twinning in addition to dislocation slip as deformation mechanism at 77 K. Our results suggest that cellular structure plays an essential role in yield strength. Moreover, the interactions of the deformation twins and cellular dislocation structures increase strain hardening and help retard plastic instability, thereby improving ductility at 77 K.11Nsciescopu

Central Role of Moral Obligations in Determining Intentions to Engage in Digital Piracy

Piracy is a significant source of concern facing software developers, music labels, and movie production companies, to name a few. Digital goods producers and government entities argue that there are victims of piracy, whereas pirates may perceive their actions to be victimless. Regarding implications of our research, we extend the theory of planned behavior (TPB) by theorizing that attitudes, subjective norms, and perceived behavioral control could influence perceptions of moral obligations as a consequence of the desire to rationalize unethical behavior. Unlike prior literature, we manipulate the rationalization of moral obligations due to the victimless view toward piracy and show how moral obligations become important determinants of piracy behavior. Accordingly, our demonstrated malleability of morals may be an important path through which individuals are able to continue past behaviors. We also conduct a second study to identify the effect of implementing an educational message from a fictitious software company to exogenously nudge the pirate and influence the impact of perceived moral obligations on intentions to pirate. Our results show that the introduction of an exogenous educational message is an effective piracy mitigation strategy.18 month embargo; published online: 26 October 2018This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]